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Date Published: 28/01/2026
Abstract Views: 103
Views PDF: 54
DOI: 10.56535/jmpm.v51i1.1747
Issue
Vol. 51 No. 1 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.1 - 2026
Section
Articles
How to Cite
Nguyen, M. H., Tran, Q. T., Tran, V. T., & Vu, M. D. (2026). CHANGES IN TROPONIN I LEVELS IN PATIENTS WITH SEPTIC SHOCK AND THEIR PROGNOSTIC VALUE FOR MORTALITY. Journal of Military Pharmaco-medicine, 51(1), 84-92. https://doi.org/10.56535/jmpm.v51i1.1747

CHANGES IN TROPONIN I LEVELS IN PATIENTS WITH SEPTIC SHOCK AND THEIR PROGNOSTIC VALUE FOR MORTALITY

Minh Hai Nguyen1, Quoc Thang Tran2, Van Tung Tran1, , Minh Duong Vu1
1 Bệnh viện Quân y 103, Học viện Quân y
2 Bệnh viện Quân y 354

Main Article Content

Abstract

Objectives: To investigate changes in plasma Troponin I concentrations in patients with septic shock and to determine their mortality prognostic value. Methods: Aprospective, cross-sectional descriptive study with longitudinal follow-up was conducted on 59 patients with septic shock at the Intensive Care, Emergency and Poison Central Center, Military Hospital 103 from January 2023 to June, 2025. Plasma Troponin I level quantified at the timepoints T0, T24h, T48h, and T72h. The relationships between Troponin I and SOFA, APACHE II, Lactate, and PCT were analyzed. The receiver operating characteristic (ROC) curve and multivariable logistic regression were used to evaluate the prognostic value. Results: The rate of increased Troponin I at T0 was 76.3%. Troponin I was positively correlated with SOFA, APACHE II, Lactate, and PCT. ROC analysis showed an AUC of 0.717, with a cut-off value of 101.3 pg/mL (Se 82.6%, Sp 52.8%). Multivariable regression identified Troponin I as an independent predictor of mortality (OR = 9.1; 95%CI: 2.1 - 40.7; p < 0.05). Conclusion:Troponin I levels are elevated in patients with septic shock and serve as an independent prognostic factor for mortality.

Keywords

Septic shock, Troponin I, Mortality prognosis, SOFA, APACHE II

Article Details

References

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